Portugal know that a win will keep them in a strong position to qualify for the European Championship finals next summer.
William Carvalho’s withdrawal from the squad follows on from Rafa Silva being released from international duty on Monday.
It comes after fitness concerns regarding another Portuguese player, William Carvalho.
The Porto midfielder came close to moving on in the summer.
Several high-profile players are included in the squad - though there is no place for Pedro Goncalves.
A story of hard work and second chances gives Semedo a lifeline in his international football career.
Fernando Santos has announced the team to take on Luxembourg and Ukraine.
A look at the team Fernando Santos could choose to face Ukraine and Luxembourg.
A look at a handful of players who are doing what it takes to make Fernando Santos’ next Portugal squad.
A look at the 35 most expensive Portuguese players when scaled up to modern-day inflation.